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Multiple Sclerosis is associated with low vitamin D via 24 paths – Nov 2024


Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality

Nutr J. 2024 Nov 30;23(1):151. doi: 10.1186/s12937-024-01059-4.
Xing-Hao Yu # 1 2 3 4 5, Hui-Min Lu # 6, Jun Li 1 2 7, Ming-Zhu Su 1 8, Xiao-Min Li 9 10 11, Yi Jin 12 13 14

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Background: Multiple Sclerosis (MS), an autoimmune disorder causing demyelination and neurological damage, has been linked to 25-hydroxyvitamin D (25OHD) levels, suggesting its role in immune response and MS onset. This study used GWAS datasets to investigate genetic associations between 25OHD and MS.

Methods: We utilized a large-scale prospective cohort to evaluate serum 25OHD levels and MS risk. Linkage Disequilibrium Score Regression (LDSC) assessed genetic correlations between 25OHD levels and MS. Cross-trait genome-wide pleiotropy analysis revealed shared genetic loci. MAGMA analysis identified pleiotropic genes, enriched tissues, and gene sets. Stratified LDSC estimated tissue-specific and cell-specific heritability enrichment, and multi-trait co-localization analysis identified shared immune cell subsets. Bidirectional Mendelian Randomization (MR) assessed the causal association between 25OHD and MS risk.

Results: The observational study found a nonlinear relationship between 25OHD levels and MS risk, with the lowest quartile showing significant risk elevation. Our findings revealed shared genetic structure between 25OHD levels and MS, suggesting a common biological pathway involving immune function and CNS integrity.

We found 24 independent loci shared between 25OHD levels and MS risk, enriched in brain tissues and involved in pathways like LDL, HDL, and TG metabolism. Four loci (6p24.3, 6p22.2, 12q14.1, and 19p13.2) had strong co-localization evidence, with mapped genes as potential drug targets. Bidirectional MR analysis supported a causal effect of 25OHD levels on MS risk, suggesting 25OHD supplementation could modulate MS risk.

Conclusion: This study reveals the complex relationship between 25OHD levels and MS, indicating that higher levels are not always advantageous and recommending moderation in supplementation. We identified SMARCA4 as a potential therapeutic target and detailed key pathways influencing this interaction.
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VitaminDWiki - 14 studies in both categories Multiple Sclerosis and the Vitamin D Receptor

This list is automatically updated


Wonder how the study missed the very important Vitamin D Receptor gene

VitaminDWiki - CYP24A1 enzyme and Vitamin D - many studies


VitaminDWiki – Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019

UV and Sunshine reduces MS risk

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High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 14 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

Attached files

ID Name Comment Uploaded Size Downloads
22049 MS 24 paths_CompressPdf.pdf admin 02 Dec, 2024 760.54 Kb 2
22048 MS 24 table.webp admin 02 Dec, 2024 22.24 Kb 13
22047 MS event rate.webp admin 02 Dec, 2024 21.30 Kb 11
22046 MS Risk.webp admin 02 Dec, 2024 15.54 Kb 16